It probably won't - this is a problem I had years ago with just that DVD2Xbox skin.
I suggest clearing the E:\drive cache and any of the content in X, Y and Z but the main issue is that DVD2Xbox creates a save settings file in your game saves.
Without checking I can't remember whether the problem file is in DVD2Xbox's E:\UDATA or E:\TDATA folder so just checked and the DVD2Xbox setting file is actually in E:\TDATA DVD2Xbox folder: 0facfac0 but delete both UDATA/TDATA 0facfac0 folders just to be certain.
Shutdown and on restart you should find DVD2Xbox reverts to the default skin.
The deleted DVD2Xbox 'game' save folders will be regenerated when you use DVD2Xbox again but with default settings. If you changed any other settings you will of course need to redo those.